ABSTRACT
Objectives: Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen activator inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system. In our study;we aimed to evaluate serum PAI-1 and other biochemical parameters of COVID-19 patients in terms of disease course and mortality. Method(s): A total of 40 COVID-19 patients were hospitalized in the service and intensive care unit (ICU) of our hospital from October to December 2020 and 20 healthy volunteers were included in our study. The patients were grouped as those who transferred to the ICU from the service and transferred to service from the ICU. The first and second values of the same patients in both the service and the ICU were analyzed by SPSS. Result(s): The PAI-1 levels of the patients in the ICU were significantly higher than the levels of the same patients in the service and the healthy control group (p<0.001). IL-6, ferritin, and D-dimer levels in the ICU of the same patients were significantly higher than the levels of service and healthy control group (p<0.001). A positive correlation was found between initial serum PAI-1 and D-dimer levels in patients hospitalized in the service (p=0.039) and initial serum ferritin and IL-6 levels in the ICU (p=0.031). Conclusion(s): In our study, we found that PAI-1 levels increased significantly with the increase in mortality in COVID-19 patients. Copyright © 2022 the author(s), published by De Gruyter.
ABSTRACT
BACKGROUND AND AIM: Studies have shown that fibrinolysis activity is insufficient in COVID-19 patients. Plasminogen Activator Inhibitor-1 (PAI-1) is an important antifibrinolytic molecule that plays a key role in the fibrinolytic system. In our study;we aimed to evaluate serum PAI-1 and other biochemical parameters of COVID-19 patients in terms of disease course and mortality. METHODS: 40 COVID-19 patients hospitalized in the service and intensive care unit of our hospital October and December 2020 and 20 healthy volunteers were included in our study. The patients were grouped as those who transferred to the intensive care unit from the service and transferred to the service from the intensive care unit. The values of the same patients in both the service and the ICU analyzed by SPSS. RESULTS: The PAI-1 levels of the patients in the intensive care unit were significantly higher than the levels of the same patients in the service and the healthy control group (p <.0001). The IL-6, ferritin, d-dimer levels of the same patients in the intensive care unit were significantly higher than their levels in the service and the healthy control group (p <.0001). A positive correlation was found between initial serum PAI-1 and d-dimer levels in the service (p=0.039) and between ferritin and IL-6 levels (p=0.031) of patients hospitalized in the intensive care unit. CONCLUSIONS: In our study, we found that with the increase in mortality in COVID-19 patients, PAI-1 levels increased significantly and decreased in patients whose clinics recovered;we also found that these values correlated with ferritin, IL-6, and d-dimer levels. Our study is one of the first studies to prospectively analyze PAI-1 levels with important biochemical parameters in COVID-19 patients. More studies are needed to elucidate the mechanism between COVID-19 and the plasminogen pathway.